All Heil FauXi!
BY Joseph Mercola TIMEDecember 27, 2021
The Substack Modern Discontent recently posted an anthology series on the benefits of quercetin, including the finding that it works like hydroxychloroquine, a drug found to be effective against SARS-CoV-2 when used early enough.
Part 1 begins with a brief overview of what quercetin is and its basic mechanisms of action. Quercetin is a flavonoid found in a variety of fruits and vegetables, such as onions and shallots, apples, broccoli, asparagus, green peppers, tomatoes, red leaf lettuce, strawberries, raspberries, blueberries, cranberries, black currants and green tea.
The quercetin content in any given food is largely dependent on light exposure, though, so depending on the country you’re in, different foods will top the list of most quercetin-rich.
Quercetin Against SARS-CoV-2
In Part 2 of the anthology, Modern Discontent reviews the evidence behind the recommendation to use quercetin against COVID-19 specifically. As mentioned, zinc has antiviral activity, and quercetin helps shuttle the zinc into the cell. But quercetin also has other mechanisms of action that make it useful in the fight against COVID-19.
Quercetin modulates NLRP3 inflammasome, an immune system component involved in the uncontrolled release of proinflammatory cytokines that occurs during a cytokine storm.
For example, quercetin has been shown to:
- Inhibit SARS-CoV-2 spike protein to ACE2 receptor docking. Computational modeling studies have shown quercetin can bind to the ACE2 receptor and the spike protein interface, thereby inhibiting the two from binding together. By preventing viral attachment, it helps prevent viral entry into the cell. Commenting on one of these studies, Modern Discontent notes:
“Although [a] computer modeled study, the evidence here suggests that quercetin’s binding activity to ACE2 is comparable to other standard of care drugs used to treat SARS-CoV-2 (eg. Remdesivir, Lopinavir, Ritonavir).”
- Inhibit lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNF-α) production in macrophages. (TNF-α is a cytokine involved in systemic inflammation, secreted by activated macrophages, a type of immune cell that digests foreign substances, microbes and other harmful or damaged components.)
- Inhibit the release of proinflammatory cytokines and histamine by modulating calcium influx into the cell.
- Stabilize mast cells and regulate the basic functional properties of immune cells, thereby allowing it to inhibit “a huge panoply of molecular targets in the micromolar concentration range, either by down-regulating or suppressing many inflammatory pathways and functions.”
- Act as a zinc ionophore, i.e., a compound that shuttles zinc into your cells. This is one of the mechanisms that can account for the effectiveness seen with hydroxychloroquine, which is also a zinc ionophore.
- Boost interferon response to viruses, including SARS-CoV-2, by inhibiting the expression of casein kinase II (CK2) — CK2 is an enzyme that is fundamental to controlling homeostasis at the cellular level. There is evidence that it down-regulates the ability a cell has to generate Type 1 interferon when attacked by a virus. However, the interferon does not function by attacking the virus. Instead, it tells the infected cell and the cells that surround the infected cell to make proteins that stop viral replication. In a nutshell, quercetin stops CK2 from interfering with the action of Type 1 interferon so cells receive the signal to stop viral replication.
- Modulate NLRP3 inflammasome, an immune system component involved in the uncontrolled release of proinflammatory cytokines that occurs during a cytokine storm.
- Exert a direct antiviral activity against SARS-CoV — Quercetin’s general antiviral capacity has been attributed to three primary mechanisms of action:
- Binding to the spike protein, thereby inhibiting its ability to infect host cells
- Inhibiting replication of already infected cells
- Reducing infected cells’ resistance to treatment with antiviral medication
- Inhibit the SARS-CoV-2 main protease.
Quercetin in COVID-19 Medical Literature
In Part 3, Modern Discontent reviews some of the clinical trials that have taken place. One COVID-19-specific study found that people who took zinc and two zinc ionophores — quinine drops and quercetin — had lower incidence of COVID-19 than the control group. Over the course of the study (20 weeks), only two of the 53 test subjects became symptomatic, compared to 12 of the 60 controls. As noted by Modern Discontent:
“Although this didn’t test quercetin in isolation, the study does suggest that over-the-counter, easily accessible compounds may be extremely beneficial in fighting against COVID, especially when taken as a prophylactic.”
In another trial, 76 outpatients who tested positive but had only mild symptoms were given 1,000 mg of Quercetin Phytosome® (quercetin in sunflower phospholipids that increase oral absorption 20-fold) per day for 30 days, in addition to standard care (analgesics, oral steroids and antibiotics). Another 76 patients were given standard of care only.
In the quercetin group, only 9.2% of participants went on to require hospitalization, compared to 28.9% of patients who received standard of care only. According to the authors:
“The results revealed a reduction in frequency and length of hospitalization, in need of non-invasive oxygen therapy, in progression to intensive care units and in number of deaths.
The results also confirmed the very high safety profile of quercetin and suggested possible anti-fatigue and pro-appetite properties. QP [Quercetin Phytosome®] is a safe agent and in combination with standard care, when used in early stage of viral infection, could aid in improving the early symptoms and help in preventing the severity of COVID-19 disease.”
Quercetin was also featured in two scientific reviews published in 2020. The first, published in in the Integrative Medicine journal in May 2020,32 highlighted quercetin’s promotion of SIRT2, which inhibits NLRP3 inflammasome.
The second review article, published in the June 19, 2020, issue of Frontiers in Immunology, highlighted quercetin’s usefulness as a COVID-19 treatment when used in conjunction with vitamin C. The vitamin C recycles oxidized quercetin, producing a synergistic effect. It also enhances quercetin’s antiviral capacity.
Food as Medicine
With the advent of processed foods, many important nutrients have been lost or minimized in the average person’s diet. Quercetin, being found in fresh fruits, vegetables and berries is one of them. Unfortunately, while essential vitamins and minerals are generally recognized for their importance, antioxidants such as quercetin are often overlooked, and sometimes labeled as “pseudoscience” or “fad” supplements. As noted by Modern Discontent:
“The great number of benefits that these compounds contribute to humans cannot be overstated … An argument can be made that not only could quercetin prove beneficial to our health, but an absence of it may prove detrimental in the long term.”
If COVID-19 has taught us anything, it’s the importance of basic health and a healthy immune function. In this regard, a diet high in fresh fruits and vegetables can go a long way. Nutritional supplements also have their place, especially in situations like a pandemic.
In conclusion, Modern Discontent provides the following summary of findings:
• “There’s evidence that quercetin may work similarly to hydroxychloroquine — It seems that quercetin may operate as both an immunomodulator and a zinc ionophore. Its use as an over-the-counter anti-allergic supplement as well as its use for asthma indicates an ability to affect the production of histamine and cytokines …
• Quercetin has plenty of other benefits — … Antioxidants … are some of the most well studied compounds, with possible anti-cancer, pro-heart and pro-organ benefits. Add on possible antimicrobial properties and it becomes hard to argue that this is nothing more than a possible fad supplement.
• Although limited, there is some evidence that quercetin may be effective against SARS-CoV2 — Computer models and in vitro studies suggest that ACE2 receptors and the main protease of SARS-CoV2 may be good target candidates for quercetin … the limited number of studies suggest quercetin may be effective, especially if used early on or as a prophylactic.
• Dietary quercetin is the main source of quercetin, and its deficiency in modern diets may be contributing to our health problems — Quercetin is primarily sourced from colorful fruits, vegetables, teas … all foods that many of our ancestors would have consumed on a regular basis … Modern ‘enriched’ foods tend to supplement with additional vitamins and minerals, but may miss out on other plant-derived compounds that have played a substantial role in our diet.
Similar to reduced sunlight exposure and the need for increased vitamin D supplementation, we may need to look at possible supplementation of overlooked compounds such as polyphenols. Sourcing these compounds from real foods would prove the most beneficial, but in groups of people who may not have access to fresh fruits and vegetables, quercetin and polyphenol supplementation may be useful.
This would include people with alternative diets such as keto, who may avoid high carb fruits, and thus may be missing a key nutrient in their diets.
Quercetin has plenty of benefits, and for those who may be missing out on it in their diet they may want to look into sourcing it with supplementation. Don’t take this as a prescription or recommendation, but an argument to examine your own health and see what you may be lacking …”
Sources and References
- Modern Discontent Quercetin Anthology Series
- Modern Discontent Quercetin Anthology Series Part 1
- Modern Discontent Quercetin Anthology Series Part 2
- Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike Protein-Human ACE2 Interface
- J. Agric Food Chem 2020 Nov 25; 68(47): 13982–13989
- Drug Dev Ind Pharm 2020; 46(8): 1345–1353
- Nutrients 2016 Mar; 8(3): 167, 5.1.2 Mechanism of Action
- Nutrients 2016 Mar; 8(3): 167, Table 1: Mast cell
- Journal of Agricultural and Food Chemistry 2014, 62, 32, 8085-8093
- Medical Hypothesis, 2020;142(109800)
- Frontiers in Immunology, 2019; doi.org/10.3389/fimmu.2019.01586
- Journal of Biological Chemistry, 2007; doi.org/10.1074/jbc.R700004200
- Mediators of Inflammation 2016; 2016, Article ID 5460302
- Journal of Virology October 2004: 11334-11339 (PDF)
- Biotechnology Letters February 15, 2012; 34: 831-838
- Bioorg Med Chem 2010 Nov 15;18(22):7940-7
- Journal of Virology 2004 Oct;78(20):11334-9
- Preprints.org March 12, 2020
- FLCCC I-MASK+ Protocol (PDF)
- Modern Discontent Quercetin Anthology Series Part 3
- J Evid Based Integr Med 2021; 26: 2515690X211026193
- Int J Gen Med 2021; 14: 2359–2366
- MedPage Today July 1, 2020
- Integrative Medicine May 9, 2020; 19(S1)
- Frontiers in Immunology June 19, 2020 DOI: 10.3389/firmmu.2020.01451
By Joseph Mercola December 25, 2021 Updated: December 25, 2021
Glycyrrhizin was valued in ancient Arabia and Greece for treating coughs and in China for relieving irritation of the mucous membranes. In modern times, glycyrrhizin has been shown to be a formidable antiviral, fighting herpes, HIV, hepatitis, influenza, encephalitis and pneumonia as well as less known viruses like respiratory syncytial virus, arboviruses, vaccinia virus and vesicular stomatitis virus.
Glycyrrhizin Has Medicinal Properties
You may think of licorice as an extract, a sweetener or even a candy, like Good and Plenty, but it’s actually complex biochemically and offers important medical benefits. According to PubChem, a database of chemical molecules maintained by the National Center for Biotechnology Information,
“Glycyrrhizic acid is extracted from the root of the licorice plant; Glycyrrhiza glabra. It is a triterpene glycoside with glycyrrhetinic acid that possesses a wide range of pharmacological and biological activities … potential immunomodulating, anti-inflammatory, hepato- and neuro-protective, and antineoplastic activities.
Glycyrrhizin modulates certain enzymes involved in inflammation and oxidative stress, and downregulates certain pro-inflammatory mediators, thereby protecting against inflammation- and reactive oxygen species (ROS)-induced damage. Glycerrhizin may also suppress the growth of susceptible tumor cells.”
According to Botanical Medicine, the anti-inflammatory actions of glycyrrhizin (GL) may stem from suppression of cytokines:
“As testimony to its anti-inflammatory properties, glycyrrhizin alleviated allergic asthma in an experimental mouse model, increased the IL-4 and IL-5 levels, decreased eosinophil counts and IgE levels, and upregulated total IgG2a in serum.
These results indicated that glycyrrhizin interfered with the production of IgE by decreasing the IgE-stimulating cytokines. It also attenuated lung inflammation and mucus production in mice.”
Glycyrrhizin and SARS
Early SARS-CoV-1 patients were given the viral compound ribavirin, but it showed little benefit. Corticosteroids were also tried in SARS-CoV-1 patients and patients with MERS (Middle East Respiratory Syndrome), which occurred 10 years later, but there was “no evidence showing that the mortality of SARS-CoV-1 and MERS patients was reduced,” as reported in the International Journal of Biological Sciences.
Soon after the SARS-CoV-1 outbreak, the medical journal The Lancet published a research letter suggesting that glycyrrhizin might fight SARS:
“The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus from patients with SARS …
Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.”
Glycyrrhizin had several positive actions, wrote the researchers:
“In addition to inhibition of virus replication, glycyrrhizin inhibits adsorption and penetration of the virus — early steps of the replicative cycle … Glycyrrhizin was most effective when given both during and after the adsorption period …
… glycyrrhizin and its aglycone metabolite 18β glycyrrhetinic acid upregulate expression of inducible nitrous oxide synthase and production of nitrous oxide in macrophages.
Nitrous oxide inhibits replication of several viruses — eg, Japanese encephalitis virus, which can also be inhibited by glycyrrhizin. Our preliminary results show that glycyrrhizin induces nitrous oxide synthase in Vero cells [cells used in cultures] and that virus replication is inhibited when the nitrous oxide donor is added to the culture medium.”
Glycyrrhizin May Act Differently From Other Substances
According to the Journal of General Virology, glycyrrhizin’s method of stopping the replication of SARS viruses may differ from other treatments that have been tried:
“Unlike IFN-α and ribavirin, there are few clues to the antiviral mechanism of glycyrrhizin. Our data indicate that, as for ribavirin, glycyrrhizin only moderately affects coronavirus replicase functions.
However, in contrast to ribavirin, glycyrrhizin has been shown to inhibit SARS-CoV replication in tissue culture. This indicates that glycyrrhizin may not target the coronavirus replication machinery and that antiviral effects may be exerted, for example, during virus adsorption or release.”
Stopping replication is especially challenging because of the peculiarities of the SARS virus. According to General Cell Biology & Physiology:
“These analyses revealed that SARS-CoV-2 reshapes central cellular pathways, such as translation, splicing, carbon metabolism and nucleic acid metabolism. Small molecule inhibitors targeting these pathways were tested in cellular infection assays and prevented viral replication.”
Glycyrrhizin’s upregulation of nitric oxide and nitric oxide synthase in macrophages, which was noted in the International Journal of Infectious Diseases, may explain its ability to stop replication of SARS and hopefully other coronaviruses like SARS-CoV-2.
Wednesday, December 29, 2021 by: Ethan Huff
In Ventura County, located to the north of Los Angeles, cases of “unexplained” heart problems, strokes and blood clotting are skyrocketing at area hospitals. And many local doctors are refusing to link these events to Wuhan coronavirus (Covid-19) injections.
A critical care nurse at a Ventura County ICU came forward to tell the Conejo Guardian that he is “tired of all the B.S. that’s going on” as the medical establishment refuses to acknowledge the elephant in the room.
“It’s crazy how nobody questions anything anymore,” this person, named Sam, is quoted as saying.
Sam says that there has been a noticeable surge in young people experiencing these types of severe health problems after they get needled with the injections from Operation Warp Speed.
“We’ve been having a lot of younger people come in,” Sam added. “We’re seeing a lot of strokes, a lot of heart attacks.”
In one case, a 38-year-old woman came to the emergency room with occlusions, or blockages of blood flow, in her brain.
“They [doctors] were searching for everything under the sun and documenting this in the chart, but nowhere do you see if she was vaccinated or not,” Sam added.
“One thing the vaccine causes is thrombosis, clotting. Here you have a 38-year-old woman who was double-vaccinated and she’s having strokes they can’t explain. None of the doctors relates it to the vaccine. It’s garbage. It’s absolute garbage.”
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The vaccine-damaged are the ones flooding hospitals
In another instance, a 63-year-old woman with no previous cardiac history suffered a heart attack. Tests revealed that her coronary arteries were clean, however she had just taken a Moderna injection.
“One doctor actually questioned the vaccine, but they didn’t mention it in the chart because you can’t prove it,” Sam said.
Sam says that hospitals all around the area are seeing a significant spike in myocarditis, a well-known adverse effect caused by Chinese Flu shots.
“Everyone wants to downplay it – ‘It’s rare, it’s rare,’” Sam laments about how the medical establishment is not taking any of this seriously.
“Doctors don’t want to question it. We have these mass vaccinations happening and we’re seeing myocarditis more frequently and nobody wants to raise the red flag. When we discuss the case, they don’t even discuss it. They don’t mention it. They act like they don’t have a reason, that it’s spontaneous.”
Another ICU nurse by the name of Dana told the Conejo Guardian that her facility has “never been this busy,” and that “none of it is Covid-19.”
“We don’t normally see this amount of strokes, aneurysms and heart attacks all happening at once,” Dana says.
“Normally we’ll see six to ten aortic dissections a year. We’ve seen six in the last month. It’s crazy. Those have very high rates of mortality.”
Almost never do the doctors at Dana’s hospital ever even consider the fact that Wuhan Flu shots might be responsible for all this. Instead, they are blaming things like “the holidays” for this sudden uptick, which makes zero sense.
“I don’t understand how you can look at what’s going on and come up with just, ‘Yeah, it’s the holidays.’ There’s been a big change in everybody’s life, and it’s the vaccine.”
The vast majority of admitted patients are fully vaccinated, and yet an unprecedented number of them, Dana says, are “on pressers to keep their blood pressure up, people on ventilators, clotting issues, so we have a lot of Heparin drips to make sure they don’t stroke out.”
More of the latest news about Fauci Flu injections can be found at ChemicalViolence.com.
Sources for this article include:
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