Unintended Consequences of mRNA Vaccines Against COVID-19

BY Joseph Mercola March 3, 2022

MIT scientist Stephanie Seneff’s paper, “Worse Than the Disease: Reviewing Some Possible Unintended Consequences of mRNA Vaccines Against COVID-19,” published in the International Journal of Vaccine Theory, Practice and Research in collaboration with Dr. Greg Nigh, is still one of the best, most comprehensive descriptions of the many possible unintended consequences of the mRNA gene transfer technologies incorrectly referred to as “COVID vaccines.”

December 9, 2021, their paper was reprinted in the Townsend Letter, the Examiner of Alternative Medicine. Seneff, Ph.D., a senior research scientist at MIT who has been conducting research at MIT for over five decades, has spent a large portion of her career investigating the hazards and mechanisms of action of glyphosate.

Her attention was diverted to the science of mRNA gene transfer technologies in early 2020, when Operation Warp Speed was announced. As noted in her paper, many factors that lacked precedent, yet were being implemented at breakneck speed, included:

  1. The first-ever use of PEG in an injection
  2. The first-ever use of mRNA gene transfer technology against an infectious agent
  3. The first-ever “vaccine” to make no clear claims about reducing infection, transmissibility or death
  4. The first-ever coronavirus vaccine ever tested on humans (and previous coronavirus vaccines all failed due to antibody-dependent enhancement, a condition in which the antibodies actually facilitate infection rather than defend against it)
  5. The first-ever use of genetically modified polynucleotides in the general population

An Insanely Reckless Process

In a May 2021 interview with me, Seneff said:

“To have developed this incredibly new technology so quickly, and to skip so many steps in the process of evaluating [its safety], it’s an insanely reckless thing that they’ve done. My instinct was that this is bad, and I needed to know [the truth].

So, I really dug into the research literature by the people who’ve developed these vaccines, and then more extensive research literature around those topics. And I don’t see how these vaccines can possibly be doing anything good …”

At the time, just five months into the mass inoculation campaign, Seneff suspected the COVID shots would end up killing far more people than the infection itself. Today, a full year into it, the statistics are grim beyond belief, proving her educated prediction to have been an astute one.

mRNA Jabs Are Shockingly Hazardous

As of December 3, 2021, the U.S. Vaccine Adverse Event Reporting System (VAERS) has logged an astounding 927,738 COVID jab related adverse events, including 19,886 deaths. VAERS can receive reports from vaccine manufacturers and other international sources, and if we exclude those, the death toll reported in U.S. territories exclusively stands at 9,136.

Of the total death reports, Pfizer — the only company that the U.S. Food and Drug Administration has granted full licensing for an as-yet unavailable COVID shot — accounts for the vast majority: 13,268, compared to 4,894 for Moderna, 1,651 for Janssen and 73 for an undisclosed brand.

Pfizer also accounts for the vast majority of hospitalizations post-injection, and while those over the age of 66 make up the bulk of deaths, the 25-to-50 age group accounts for most of the hospitalizations. Key side effects that are now being reported in massive numbers include:

  • Miscarriages
  • Heart problems such as heart attacks and myopericarditis
  • Thrombocytopenia (low platelet count)
  • Shingles
  • Bell’s palsy
  • A variety of permanent disabilities, many of which involve neurological dysfunction

All of these consequences were predicted by Seneff and Nigh in their paper, which makes the events all the more tragic. Importantly, VAERS is notoriously underreported, so the real-world impact of these shots is far greater than what those data suggest.

The Cure Is Indeed Worse Than the Disease

Calculations performed by Steve Kirsch, executive director of the COVID-19 Early Treatment Fund, and his team of statisticians suggest VAERS COVID-related reports are underreported by a factor of 41. This is a conservative estimate, supported by calculations using a variety of sources besides VAERS itself.

That means that in the U.S. alone (using the data for U.S. territories only), the actual death toll may be closer to 374,576 (including international deaths reported to VAERS would put the death toll at 815,326), and those are deaths that occurred within days or weeks post-injection.

As Seneff and Nigh explain in their paper, there’s overwhelming reason to suspect that these gene transfer injections will have devastating impacts in the long term, resulting in excess deaths over the next decade.

What’s more, it’s clear that the death toll from the COVID-19 infection itself in the U.S. has been vastly exaggerated, as it’s based on positive PCR tests and even mere suspicion of COVID in the absence of testing. Many died from other causes and just happened to have a positive COVID test at the time of death.

Kirsch estimates the real death tally from COVID-19 to be about 50% of the reported number (which is likely conservative). This means about 380,000 Americans died from COVID-19 (rather than with COVID), whereas the COVID shots may have killed more than 374,570 in the first 11 months alone.

“Seneff suspects that in the next 10 to 15 years, we’ll see a dramatic spike in prion diseases, autoimmune diseases, neurodegenerative diseases at younger ages, and blood disorders such as blood clots, hemorrhaging, stroke and heart failure.”

As predicted in the title of Seneff’s paper, it seems the cure may indeed end up being worse than the disease. This is particularly true for children and young adults, who have either died or been permanently disabled by the shots by the thousands, while having an extraordinarily low risk of dying from or being seriously harmed by the infection itself.

Seneff suspects that in the next 10 to 15 years, we’ll see a dramatic spike in prion diseases, autoimmune diseases, neurodegenerative diseases at younger ages, and blood disorders such as blood clots, hemorrhaging, stroke and heart failure.

The Spike Protein Is the Most Dangerous Part of SARS-CoV-2

The reason we’re seeing all these problems from the COVID shots is because they program your cells to continuously produce SARS-CoV-2 spike protein, which we now know is the most dangerous part of the virus. Many experts noted this from the start, wondering what the vaccine developers could possibly be thinking, selecting this as the antigen for their shots.

While the mRNA injections can cause harm in many different ways, one basic problem is that they can overstimulate your immune system to the point of failure. In summary, as your cells start producing the viral spike proteins, your immune cells rally to mop up the proteins and dump them into your lymphatic system. (This is why many report swollen lymph nodes under the arms.)

The antibody response is part of your humoral immunity. You also have cellular immunity, which is part of your innate immune system. Your innate immune system is very powerful. If you’re healthy, it can clear viruses without ever producing a single antibody. Antibodies are actually a second-tier effect when your innate immune system fails.

The problem is that your innate immune system will not be activated and likely will fail to protect you if you get a COVID-19 shot, because it’s bypassing all of the areas where your innate immune system would be brought to bear.

Normally you breathe the virus in and stimulate the production secretory IgA antibodies that protect your respiratory system. When you bypass that route of exposure with a jab in the arm, no secretory IgA antibodies are produced, leaving you susceptible to the infection.

As explained by Ronald Kostoff in an excellent December 8, 2021, Trial Site News article, “COVID-19 ‘Vaccines’: The Wrong Bomb Over the Wrong Target at the Wrong Time”:

“An effective vaccine would focus on cellular immunity in the respiratory and intestinal tract, in which secretory IgA is produced by your lymphocytes that are located directly underneath the mucous membranes that line the respiratory and intestinal tract.

The antibodies produced by these lymphocytes are ejected through and to the surface of the linings. These antibodies are thus on site to meet air-borne viruses and they may be able to prevent viral binding and infection of the cells.

Unfortunately, the main inoculants used presently for COVID-19 focus on antibodies (IgG and circulating IgA) that occur in the bloodstream. These antibodies protect the internal organs of the body from infectious agents that try to spread via the bloodstream.”

When you are injected with the COVID jab, your body will only induce IgG and circulating IgA — not secretory IgA, and these types of antibodies do not effectively protect your mucous membranes from SARS-CoV-2 infection. So, as noted by Kostoff, the breakthrough infections we’re now seeing “confirm the fundamental design flaws” of this gene transfer technology.

“A natural infection with SARS-CoV-2 (coronavirus) will in most individuals remain localized to the respiratory tract,” Kostoff writes. “The vaccines used presently cause cells deep inside our body to express the viral spike protein, which they were never meant to do by nature.

Any cell which expresses this foreign antigen on its surface will come under attack by the immune system, which will involve both IgG antibodies and cytotoxic T-lymphocytes. This may occur in any organ, but the damage will be most severe in vital organs.

We are seeing now that the heart is affected in many young people, leading to myocarditis or even sudden cardiac arrest and death. In other words, we are dropping the wrong bomb on the wrong target at the wrong time!”

In the end, your body will essentially believe that your innate immune system has failed, which means it must bring in the backup cavalry. In essence, your body is now overreacting to something that isn’t true. You’re not actually infected with a virus and your innate immune system has not failed, but your body is forced to respond as if both are true.

Effects Likely to Persist Long Term

What’s more, the synthetic RNA in the mRNA vaccines contains a nucleotide called methyl-pseudouridine, which your body cannot break down, and the RNA is programmed to trigger maximum protein production. So, we’re looking at completely untested manipulation of RNA.

It is very important to recognize that this is a genetically engineered mRNA for the spike protein. It is not identical to the spike protein mRNA that SARS-Cov-2 produces. It’s been significantly altered to avoid being metabolized by your body.

The spike protein your body produces in response to the COVID-19 vaccine mRNA locks into your ACE2 receptor. This is because the genetically engineered new spike protein has additional prolines inserted that prevent the receptors from properly closing, which then cause you to downregulate ACE2. That’s partially how you end up with problems such as pulmonary hypertension, ventricular heart failure and stroke.

As noted in a 2020 paper, there’s a “pivotal link” between ACE2 deficiency and SARS-CoV-2 infection. People with ACE2 deficiency tend to be more prone to severe COVID-19. The spike protein suppresses ACE2, making the deficiency even worse. According to Seneff, the gene transfer injections essentially do the same thing, and we still don’t know how long the effects last.

Manufacturers initially guessed the synthetic RNA might survive in the human body for about six months. A more recent investigation found the spike protein persisted in recovered COVID patients for 15 months.

This raises the suspicion that the synthetic and more persistent mRNA in the COVID shots may trigger spike protein production for at least as long, and probably longer. What’s more, the number of spike proteins produced by the shots is far greater than what you experience in natural infection.

As explained by Dr. Peter McCullough, this means that after your first shot, your body will produce spike protein for at least 15 months. But, when you get shot No. 2 a few weeks later, that shot will cause spike protein production to go on for 15 months or longer. With shot No. 3 six months after that, you produce spike protein for yet another 15 months.

With regular boosters, you may never rid your body of the spike protein. All the while, it’s wreaking havoc with your biology. McCullough likens it to “a permanent install of an inflammatory protein in the human body,” and inflammation is at the heart of most if not all chronic diseases. There’s simply no possible way for these gene transfer shots to improve public health. They’re going to decimate it.

Long-Term Neurological Damage Is To Be Expected

In her paper, Seneff describes several key characteristics of the SARS-CoV-2 spike protein that suggests it acts as a prion. This could help explain why we’re seeing so many neurological side effects from the shots. According to Seneff, the spike protein produced by the COVID shot, due to the modifications made, may actually make it more of a prion than the spike protein in the actual virus, and a more effective one.

For a detailed technical description of this you can read through Seneff’s paper, but the take-home message is that COVID-19 shots are instruction sets for your body to make a toxic protein that will eventually wind up concentrated in your spleen, from where prion-like protein instructions will be sent out, radically increasing your risk of developing neurodegenerative diseases.

Lung, Heart and Brain Diseases Are Predictable Consequences

Seneff also goes into great detail describing how the spike protein acts as a metabolic poison. While I recommend reading Seneff’s paper in its entirety, I’ve extracted some key sections below, starting with how the spike protein can trigger pathological damage leading to lung damage and heart and brain diseases:

“The picture is now emerging that SARS-CoV-2 has serious effects on the vasculature in multiple organs, including the brain vasculature … In a series of papers, Yuichiro Suzuki in collaboration with other authors presented a strong argument that the spike protein by itself can cause a signaling response in the vasculature with potentially widespread consequences.

These authors observed that, in severe cases of COVID-19, SARS-CoV-2 causes significant morphological changes to the pulmonary vasculature … Furthermore, they showed that exposure of cultured human pulmonary artery smooth muscle cells to the SARS-CoV-2 spike protein S1 subunit was sufficient to promote cell signaling without the rest of the virus components.

Follow-on papers showed that the spike protein S1 subunit suppresses ACE2, causing a condition resembling pulmonary arterial hypertension (PAH), a severe lung disease with very high mortality … The ‘in vivo studies’ they referred to … had shown that SARS coronavirus-induced lung injury was primarily due to inhibition of ACE2 by the SARS-CoV spike protein, causing a large increase in angiotensin-II.

Suzuki et al. (2021) went on to demonstrate experimentally that the S1 component of the SARS-CoV-2 virus, at a low concentration … activated the MEK/ERK/MAPK signaling pathway to promote cell growth. They speculated that these effects would not be restricted to the lung vasculature.

The signaling cascade triggered in the heart vasculature would cause coronary artery disease, and activation in the brain could lead to stroke. Systemic hypertension would also be predicted. They hypothesized that this ability of the spike protein to promote pulmonary arterial hypertension could predispose patients who recover from SARS-CoV-2 to later develop right ventricular heart failure.

Furthermore, they suggested that a similar effect could happen in response to the mRNA vaccines, and they warned of potential long-term consequences to both children and adults who received COVID-19 vaccines based on the spike protein.

An interesting study by Lei et. al. (2021) found that pseudovirus — spheres decorated with the SARS-CoV-2 S1 protein but lacking any viral DNA in their core — caused inflammation and damage in both the arteries and lungs of mice exposed intratracheally.

They then exposed healthy human endothelial cells to the same pseudovirus particles. Binding of these particles to endothelial ACE2 receptors led to mitochondrial damage and fragmentation in those endothelial cells, leading to the characteristic pathological changes in the associated tissue.

This study makes it clear that spike protein alone, unassociated with the rest of the viral genome, is sufficient to cause the endothelial damage associated with COVID-19. The implications for vaccines intended to cause cells to manufacture the spike protein are clear and are an obvious cause for concern.”

The COVID Shots Activate Latent Viruses

As mentioned earlier, shingles infection is turning out to be a rather common side effect of the COVID shot, and like the neurological, vascular and cardiac damage we’re seeing, activation of latent viral infections was also predicted.

One reason why latent viral infections are cropping up in response to the shots is because the shots disable your type I interferon pathway. A second reason is because your immune system is overburdened trying to deal with the inflammatory spike proteins flowing through your body. Something’s got to give, so latent viruses are allowed to break through.

That’s not the end of your potential troubles, however, as these coinfections may worsen or accelerate other conditions, such as Bell’s Palsy, myalgic encephalomyelitis and chronic fatigue syndrome.

Herpes viruses, for example, have been implicated as a trigger of both AIDS and chronic fatigue syndrome. Some research suggests these diseases don’t appear until viruses from different families partner up and the type 1 interferon pathway is disabled.

With all of that in mind, it seems inevitable that, long term, the COVID mass injection campaign will result in an avalanche of a wide range of debilitating chronic illnesses.


International Journal of Vaccine Theory, Practice and Research May 10, 2021; 2(1): 38-79

Townsend Letter December 9, 2021

OpenVAERS data as of December 3, 2021

OpenVAERS data as of December 3, 2021. For US only data, flip the selection switch at top

OpenVAERS Adverse Event Reports Breakdown


Trial Site News December 8, 2021

Trial Site News December 8, 2021

European Heart Journal July 20, 2020: ehaa534

Circulation Research 2021; 128: 1323-1326

European Journal of Internal Medicine June 2020; 76:14-20

Circulation Research 2021; 128: 1323-1326

bioRxiv June 25, 2021 DOI: 10.1101/2021.06.25.449905

New American November 8, 2021 , video at circa 8 minutes

New American November 8, 2021 , video at circa 8 minutes

International Journal of Vaccine Theory, Practice and Research May 10, 2021; 2(1): 402-444

International Journal of Vaccine Theory, Practice and Research May 10, 2021; 2(1): 402-444

Journal of Antimicrobial Chemotherapy 1996 37. Suppl B, 87-95

ImmunoHorizons April 1, 2020


Joseph Mercola

Dr. Joseph Mercola is the founder of Mercola.com. An osteopathic physician, best-selling author, and recipient of multiple awards in the field of natural health, his primary vision is to change the modern health paradigm by providing people with a valuable resource to help them take control of their health.

US bioweapons labs CONFIRMED as deep state sets stage for biowar false flag event to be blamed on Russia

Thursday, March 10, 2022 by: Mike Adams

(Natural News) Earlier this week, US Under Secretary of State Victoria Nuland publicly confirmed the presence of US-funded bioweapons laboratories in Ukraine. She even warned that Russia might seize the facilities and launch a biological weapons false flag attack on the world to blame America.

This is a direct confirmation that the US-funded labs contain dangerous biological weapons. Otherwise, why would Nuland be concerned if Russia seized the labs?

Nuland was being questioned by US Sen. Marco Rubio, a known RINO and war machine collaborator. It appears that Rubio and Nuland rehearsed this exchange and performed it for public consumption in order to set the stage for a US false flag bioweapons release that will be blamed on Russia.



What’s fascinating is that today, State Department spokesperson Ned Price publicly denied the existence of these biological weapons research facilities in Ukraine, claiming it was all part of a “Russian disinformation” campaign.

Is Ned Price saying that Victoria Nuland works for the Russians? Are we really to believe that the US has no biological weapons facilities at all? No one believes Ned Price. Not even the US Under Secretary of State.

The US built the SARS-CoV-2 bioweapon and handed it to China

Never forget the US government — directed by Fauci and Collins — violated international treaties and built the SARS-CoV-2 bioweapon via the US DoD and various universities (North Carolina / Baric, etc.). This bioweapon was then handed to China for gain-of-function enhancement, while in the USA, it was used to create depopulation “vaccines” modeled on the deadly spike protein.

The “plandemic” was then released upon the world via US and China deep state operatives, while the controlled media pushed a psychological terrorism campaign to drive people into masking, social distancing, lockdowns and domestic economic destruction. This was followed by strong coercion for “vaccine” injections which turned out to be mRNA gene therapy transhumanism jabs designed to exterminate billions of human beings.

This was all done by the United States and China, without any involvement from Russia, just for the record. So when the USA now points to Russia and screams, “War crimes!” it all seems incredibly absurd. Laughable.

The cover story for next next bioweapon / toxic nanoparticle dumping onto humanity?

Whether the bioweapons labs are actually producing self-replicating viruses or just really dangerous nanoparticles is almost irrelevant at this point. Either way, it’s now clear they plan to dump their bioweapons onto the populations of the world while blaming Putin for a bioweapons false flag operation. The release of this bioweapon / nanoparticle is probably imminent.

That means the globalists are really moving into what they hope will be the final phase of their extermination agenda, and it’s likely to be accompanied by a global financial reset, cyber warfare false flags and the complete suspension of elections and the Bill of Rights. This is the direction in which things are moving right now, and while there may still be time to stop the worst case scenario from being unleashed, there isn’t currently any convincing evidence that the “white hats” are in charge.

All we see on a daily basis is Joe Biden deliberately unleashing economic destruction on America while his handlers (Obama, etc.) are plunging the US into what they hope will be a nuclear exchange with Russia. Yes, they are death cultists and they are hoping to achieve a scenario where Russia nukes the United States into oblivion. This is the goal of Obama, Biden and the top Democrats who currently appear to be in charge of US “policy” if you can even call it that.

Today’s Situation Update podcast covers this in more detail, including some good news about why we can dismiss the psychological terrorism attempts by the complicit media and the “science” authorities (who are all fraudsters and liars, it turns out).

The bioweapons discussion starts at 36:40. The first 36 minutes contain a special discussion specifically directed to the audience, and most people won’t understanding what we’re talking about unless they are frequent listeners:


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Fully vaccinated and boosted make up vast majority of COVID-19 cases, hospitalizations and deaths in the UK

Friday, March 11, 2022 by: Arsenio Toledo

(Natural News) Data from the United Kingdom show that Wuhan coronavirus (COVID-19) deaths among the unvaccinated have plummeted, while COVID-19 deaths from the country’s vaccinated population continue to surge.

This claim is confirmed by a report from the U.K. Health Security Agency (UKHSA), a government agency less than a year old that was formed to be the British government’s health improvement and health protection agency.

As part of its duties, the UKHSA regularly published COVID-19 Vaccine Surveillance Reports. These reports contain data on COVID-19-related cases, hospitalizations and deaths. The reports also group the information based on the vaccination status of the patient or the deceased.

One of the agency’s latest reports, published March 3, proves that the fully vaccinated and those who have received booster doses of the vaccine make up the vast majority of COVID-19 cases in the United Kingdom.

“[The report] does absolutely no favors for Pfizer and the claimed efficacy of its COVID-19 injection,” wrote the Daily Expose in an article covering the latest UKHSA report.

It should also be noted that the U.K. is dealing with a surge in COVID-19 cases. On March 6, the government confirmed 71,259 new COVID-19 cases, the highest number of new cases in over a month and up by 56 percent from last week.

The government also recorded 1,406 new COVID-related admissions into hospitals on that day, up by a third from last week and it is the seventh day in a row where COVID-19 hospitalizations have risen week-on-week.

Seventy-nine percent of the British population has received at least one dose of the vaccine. Seventy-three percent are fully vaccinated and 57 percent are fully vaccinated and boosted.

Children likely getting infected by fully vaccinated parents

The UKHSA’s March 3 report covers cases, hospitalizations and deaths by vaccination status in England between Jan. 31 and Feb. 27.

It shows that, of the nearly 1.1 million COVID-19 cases reported in England during this period, 846,616 – or 77 percent of all cases – were vaccinated and only 244,313 were unvaccinated.

Of the vaccinated cases, 67,669 were partially vaccinated, 162,998 were fully vaccinated and a whopping 615,949 were fully vaccinated and boosted.

The data also shows that more than half of the unvaccinated COVID-19 cases – 169,482 – are under 18 years old. This means children are most likely getting infected with COVID-19 through their fully or triple-vaccinated parents, other loved ones or possibly even their teachers. (Related: Fully vaccinated individuals are SHEDDING GRAPHENE and infecting the unvaccinated, causing serious health complications.)

UKHSA’s report shows that between Jan. 31 and Feb. 27, there were a total of 7,931 confirmed COVID-related hospitalizations in England. Of those, only 1,832 were unvaccinated and the remaining 6,099 were vaccinated. Among the unvaccinated hospitalizations, 812 were among children.

Of the vaccinated hospitalized COVID-19 cases, 363 were partially vaccinated, 1,178 were fully vaccinated and 4,558 were fully vaccinated and boosted.

A similar situation can be seen when looking at COVID-19 deaths during this time. There were a total of 3,939 confirmed COVID-19 deaths in England. Unvaccinated individuals only account for 397 of these deaths. This means that the vaccinated individuals account for 90 percent of all COVID-19 deaths in England.

Among the 3,542 vaccinated COVID-19 deaths, 113 were partially vaccinated, 725 were fully vaccinated and a whopping 2,704 were fully vaccinated and boosted at the time of their death.

Instead of looking at this data and using it to push for an end to vaccinations in England, the government is preparing to administer the fourth dose of the COVID-19 vaccines later this month. The first groups eligible for this second booster include people over 75, care home residents and people with weakened immune systems.

More related stories:

MP Christopher Chope urges British government to support individuals suffering from COVID vaccine injuries.

Covid injection injury payouts in U.K. set to outpace 40 years of combined vax damage disbursements.

UK government data proves COVID-19 vaccines continue to damage immune systems over time, creating vaccine-induced “AIDS.”

British media claim “stealth disease,” not COVID-19 vaccines, could kill nearly 200,000 people in UK over the next five years.

COVID cover-up: UK media refuses to report that 4 of 5 coronavirus deaths over the past month occurred in the vaccinated.

Listen to this clip of Dr. Robert Malone, creator of mRNA technology, talking about how a vast majority of people dying of COVID-19 in the United Kingdom are vaccinated.


This video is from the Covid Times channel on Brighteon.com.

Read more stories about vaccine-related deaths at VaccineDeaths.com.

Sources include:


Assets.Publishing.Service.gov.uk [PDF]




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The Absolute Worst Cooking Oils for Your Health

BY Joseph Mercola March 9, 2022

Your choice of cooking oil can make a profound difference in your health. I’ve often warned against the use of soybean oil. Not only is partially hydrogenated soybean oil loaded with trans fat, which has been linked to heart disease, it’s also a source of an omega-6 fat called linoleic acid (LA), which is highly susceptible to oxidation and is typically from GMO seeds.

The problem results once you start to digest this fat, as you break it down into harmful sub-components called advanced lipid oxidation end products (ALEs) and oxidized LA metabolites (OXLAMs) that can cause significant damage at the cellular level. For example, an ALE called 4HNE is a mutagen known to cause DNA damage. Studies have shown there’s a definite correlation between elevated levels of 4HNE and heart failure.

Additionally, LA breaks down into 4HNE faster when the oil it is contained in is heated. This is largely why cardiologists recommend avoiding fried foods. ALEs and OXLAMs also play a very significant role in cancer and heart disease.

LA-Rich Soybean Oil Linked to Obesity and Diabetes

In 2015, a UC Riverside research team found soybean oil induced obesity, insulin resistance, diabetes and fatty liver in mice. Two years later, they confirmed this by showing soybean oil modified to be low in LA caused less obesity and insulin resistance than the unmodified soybean oil.

“The dogma is that saturated fat is bad and unsaturated fat is good. Soybean oil is a polyunsaturated fat, but the idea that it’s good for you is just not proven.” ~ Frances Sladek, UC Riverside toxicologist

Then, in 2020, that same team published research showing soybean oil, both the modified and unmodified versions, actually produced genetic changes in the brains of mice, and they were not for the better. However, this time LA was not the primary culprit.

Soybean Oil Linked to Genetic Changes in the Brain

In this surprising study, the researchers compared diets high in three different types of fat.

  1. Soybean oil, which has a high LA content
  2. Soybean oil modified to be low in LA
  3. Coconut oil

It is surprising, because I would have thought that the LA produced the damaging effects, but LA was ruled out. So, they have identified yet another reason to avoid consuming soy products. As reported by the UC Riverside, the researchers:

“… did not find any difference between the modified and unmodified soybean oil’s effects on the brain. Specifically, the scientists found pronounced effects of the oil on the hypothalamus, where a number of critical processes take place.

‘The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and physical growth as well as your response to stress,’ said Margarita Curras-Collazo, a UC Riverside associate professor of neuroscience and lead author on the study.

The team determined a number of genes in mice fed soybean oil were not functioning correctly. One such gene produces the ‘love’ hormone, oxytocin. In soybean oil-fed mice, levels of oxytocin in the hypothalamus went down.

The research team discovered roughly 100 other genes also affected by the soybean oil diet. They believe this discovery could have ramifications not just for energy metabolism, but also for proper brain function and diseases such as autism or Parkinson’s disease …

[T]he research team has not yet isolated which chemicals in the oil are responsible for the changes they found in the hypothalamus. But they have ruled out two candidates.

It is not linoleic acid, since the modified oil also produced genetic disruptions; nor is it stigmasterol, a cholesterol-like chemical found naturally in soybean oil. Identifying the compounds responsible for the negative effects is an important area for the team’s future research …

‘The dogma is that saturated fat is bad and unsaturated fat is good. Soybean oil is a polyunsaturated fat, but the idea that it’s good for you is just not proven,’ [UC Riverside toxicologist Frances] Sladek said.

Indeed, coconut oil, which contains saturated fats, produced very few changes in the hypothalamic genes. ‘If there’s one message I want people to take away, it’s this: reduce consumption of soybean oil,’ [assistant project scientist Poonamjot] Deol said …”

Seed Oils — A Most Harmful Ingredient in the Modern Diet

While that UC Riverside study claimed the genetic changes in the brain applied only to soybean oil and no other vegetable oils, there are loads of other research showing vegetable oils, also known as seed oils, are some of the most harmful foods you could eat.

In the video above, Dr. Chris Knobbe, an ophthalmologist and founder and president of the Cure AMD Foundation, a nonprofit dedicated to the prevention of age-related macular degeneration (AMD), gives an excellent synopsis of why seed oils are the unifying mechanism behind westernized chronic diseases like heart disease, obesity, cancer and diabetes. Some of the points he makes are:

Heart disease, now the leading cause of death in the U.S., was virtually unknown in the 19th century. The same goes for cancer, which caused 0.5% of deaths in 1811 and 5.8% of deaths in 1900 — spiking to more than 31% of deaths in 2010.

A similar pattern emerged for diabetes, which was rare in the 19th century and had a prevalence of 0.37% in 1935. By 2020, there was a 28-fold increase in 85 years, to a prevalence of 10.5%.

Obesity? Same story. With a prevalence of just 1.2% in the 19th century, obesity increased 33-fold in 115 years, to a prevalence of 39.8% in 2015. By 1990, meanwhile, 24% of U.S. adults were diagnosed with metabolic syndrome, which is a combination of high blood pressure, dyslipidemia, insulin resistance, hyperglycemia and visceral obesity.

By 2015, 88% of U.S. adults failed to meet five criteria for metabolic health, measured by blood glucose, triglycerides, HDL cholesterol, blood pressure and waist circumference.

Macular degeneration and osteoarthritis followed similar striking increases, causing Knobbe to ask, “What was so ubiquitous during this time that could have prompted these changes?” Dietary history provides the answer, with the introduction of four primary processed foods — sugar, industrially processed seed oils, refined flour and trans fats — acting as the culprits.

Seed Oils Are Incredibly Proinflammatory

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The problem with seed oils is that they’re incredibly proinflammatory and they increase excessive oxidative damage in your body. This oxidative stress, in turn, triggers mitochondrial damage and dysfunction that then drives the disease process. Several studies have demonstrated the truth of this.

The OXLAMs (LA metabolites) are also cytotoxic, genotoxic, mutagenic, carcinogenic, thrombogenic, atherogenic and obesogenic. Then, there’s the issue of direct toxicity from pesticides and herbicides.

Most of the vegetable oils produced today — especially canola, corn and soy — are made from genetically engineered crops and are therefore a significant source of toxic glyphosate exposure. According to Knobbe, the reason these oils have been able to remain in the food supply, despite their high toxicity, is because they’re not acute biological poisons, but chronic ones.

Seed oils were introduced into the U.S. diet in 1866. By 2010, they made up 32% of Americans’ diet, which amounts to 80 grams per person per day. In contrast, in 1865, most people would have only about 2% to 3% of their caloric intake from omega-6 LA from butter, lard and beef tallow.

Ancestrally raised animals had very low omega-6, but this changed significantly once animals started being raised in concentrated animal feeding operations (CAFOs). CAFO pork, for example, can contain up to 20% omega-6 fats, thanks to them being fed a diet high in omega-6 grains. The results of this dietary change have been significant.

Today, omega-6 fats make up anywhere from 20% to 30% of the average person’s daily calories, with 80% of it being LA. Instead of 80 grams per day, your goal is to get it under 7 grams per day. That would but you into the healthy percentage range of LA that our ancestors from a mere 150 years ago consumed.

According to a report by Jeff Nobbs, 6 in 10 Americans have a chronic disease, and heart disease, asthma, cancer and diabetes have increased 700% since 1935. During this time, Americans have been smoking and drinking less, exercising more and eating “healthier” according to conventional guidelines to lower saturated fat and sodium. Nobbs, too, believes seed oil is the missing link that explains why Americans keep getting sicker.

Processed Seed Oils Harm Your Health in Many Ways

Aside from oxidation, inflammation and mitochondrial dysfunction, processed seed oils and vegetable oils like soybean oil also harm your health in other ways. For example, they’ve been found to:

1.Damage the endothelium (the cells lining your blood vessels) and cause an increase in penetration of LDL and very low-density lipoprotein (VLDL) particles into the subendothelium.

In other words, these oils get integrated in your cell and mitochondrial membranes, and once these membranes are damaged, it sets the stage for all sorts of health problems. With a half-life of 600 to 680 days, it can take years to clear them out of your body. They also get incorporated into tissues such as your heart and brain. One result of this could be memory impairment and increased risk of Alzheimer’s disease. Canola oil, in particular, has been linked to Alzheimer’s.

2. Make your cell membranes more permeable, allowing things to enter that shouldn’t.

3. Make your cell membranes less fluid, which impacts hormone transporters in the cell membrane and slows your metabolic rate.

4. Inhibit cardiolipin, an important fat in the inner membrane of your mitochondria that needs to have non-damaged fat to perform optimally and facilitate optimal function of the electron transport chain and production of ATP.

Cardiolipin also works like a cellular alarm system that triggers apoptosis (cell death) by signaling caspase-3 when something goes wrong with the cell. If the cardiolipin is not saturated with DHA, it cannot signal caspase-3, and hence apoptosis does not occur. As a result, dysfunctional cells are allowed to continue to grow, which can turn into a cancerous cell.

5. Inhibit the removal of senescent cells, i.e., aged, damaged or crippled cells that have lost the ability to reproduce and produce inflammatory cytokines that rapidly accelerate disease and aging.

6. Strip your liver of glutathione (which produces antioxidant enzymes), thereby lowering your antioxidant defenses.

7. Inhibit delta-6 desaturase (delta-6), an enzyme involved in the conversion of short-chained omega-3s to longer chained omega-3s in your liver.

8. Impair your immune function and increase mortality from COVID-19. Saturated fat, on the other hand, may lower your risk of death. The authors of that study noted that unsaturated fats “cause injury [and] organ failure resembling COVID-19.”

More specifically, unsaturated fats are known to trigger lipotoxic acute pancreatitis, and the sepsis and multisystem organ failure seen in severe cases of COVID-19 greatly resembles this condition. In short, linoleic acid contributes to the inflammatory domino effect that eventually kills some people with COVID-19.

How to Avoid These Dangerous Fats

Considering the profoundly serious damage they cause, eliminating seed and vegetable oils from your diet can go a long way toward improving your health. This includes soy, canola, sunflower, grapeseed, corn, safflower, peanut and rice bran oil.

Also, be mindful of olive oil and avocado oil, as both are commonly adulterated with cheaper seed oils. That said, even pure olive and avocado oil are loaded with LA. If, like me, you’re in the habit of eating olive oil, I would strongly encourage you to limit your intake to 1 tablespoon per day or less. In my view, olive oil is not a magic bullet and if you are already consuming 80 grams of LA per day, it will only worsen, not help, your health.

To avoid these oils, don’t cook with them, of course, but also avoid processed foods, condiments, fast foods and restaurant foods. If you eat out, you’re undoubtedly eating unhealthy amounts of seed oils, as most restaurant foods are loaded with it.

Fried foods, dressing and sauces tend to be key culprits. Your best bet is to prepare most of your food at home, so you know what you are eating and, in the case of seed oils, what you’re not.

Conventionally raised chicken and pork are also very high in LA, and therefore best avoided. As mentioned earlier, CAFO animals are routinely fed grains such as corn, and as a result, their meat becomes high in LA, as the corn is loaded with it. You can learn more about this in Joe Rogan’s interview with Dr. Paul Saladino, author of “The Carnivore Code.”

How Much Linoleic Acid Is Too Much?

Many now understand that your omega-6 to omega-3 ratio is very important, and should be about 1-to-1 or possibly up to 4-to-1, but simply increasing your omega-3 intake won’t counteract the damage done by excessive LA. You really need to minimize the omega-6 to prevent damage from taking place.

Ideally, consider cutting LA down to below 7 grams per day, which is close to what our ancestors used to get before all of these chronic health conditions, including obesity, diabetes, heart disease and cancer, became widespread. If olive oil puts you over the limit, consider cooking with tallow or lard instead.

If you’re not sure how much you’re eating, enter your food intake into Cronometer — a free online nutrition tracker — and it will provide you with your total LA intake. The key to accurate entry is to carefully weigh your food with a digital kitchen scale so you can enter the weight of your food to the nearest gram.

Cronometer will tell you how much omega-6 you’re getting from your food down to the 10th of a gram, and you can assume 90% of that is LA. Anything over 10 grams is likely to cause problems.



Joseph Mercola


Dr. Joseph Mercola is the founder of Mercola.com. An osteopathic physician, best-selling author, and recipient of multiple awards in the field of natural health, his primary vision is to change the modern health paradigm by providing people with a valuable resource to help them take control of their health.